Established in 1905 by the British government, the Central Research Institute (CRI) was initially created to combat diseases prevalent in India during that era. It played a crucial role in developing vaccines for diseases like typhoid, cholera, and smallpox. The institute was instrumental in early research on rabies and the production of the anti-rabies vaccine. Over the years, CRI has expanded its research areas to include various viral and bacterial diseases, becoming a leading center for medical research and vaccine development in India. Its historical significance lies in its contributions to public health and its role in shaping India's scientific landscape.